Endocrine Abstracts

Background: Adolescent polycystic ovarian syndrome (PCOS) is being diagnosed more frequently as the prevalence of childhood obesity increases. Adolescent PCOS has been associated with low birth weight (LBW), exaggerated adrenarche (EA) and metabolic syndrome in Mediterranean populations. This study describes the clinical phenotype of a cohort of northern European girls.Methods: A retrospective study of adolescents with PCOS, diagnosed according to the Ro...

Background: Hypocortisolaemia is common in neonates1 and infants following cardiac surgery.2 In critically ill children with other pathologies, hypocortisolaemia may result from accelerated cortisol metabolism and reduced protein binding. However, the timing and frequency of normalisation of cortisol concentrations following infantile critical illness is poorly described.Objective: To describe the natural history of hypocortisolaemi...

Introduction: We evaluated Twin Precision Treatment (TPT) approach, a cluster of Internet of Things (IoT) and Artificial Intelligence (AI), validated biosensors and Continuous Glucose Monitoring (CGM) through Ambulatory Glucose Profile (AGP) integrated with machine learning algorithms, enabling physicians to empower patients to reverse diabetes.Methods: 64 T2DM (19 males, 45 female), registered on Twin Health TM service, managed by standard care of appro...

Introduction: Besides its role in calcium homeostasis, vitamin D (VD) has an important immune mudulation effect. However, its role in autoimmune diseases such as type 1 diabetes is under discussion. In this study, we aimed to assess VD status in children and adolescents with type 1 diabetes mellitus (T1DM).Material and Methods: This is a retrospective descriptive study realized at the endocrinology–diabetology department of OUJDA’s Mohammed V...

Kallmann syndrome is a rare congenital hypogonadotropic hypogonadism with variable degrees of hyposomia to anosmia. This syndrome can be transmitted as autosomal dominant, autosomal recessive and X-linked inheritance pattern. We are reporting two cases of young male siblings (17 and 16 years old) who are the offspring of unrelated parents, presenting with delayed puberty and both were complaining of hyposmia. Their older brother, aged 24 years, was diagnosed with isolated hypo...

Background: Up to 50% of children treated with inhaled corticosteroids (ICS) have biochemical evidence of adrenal insufficiency (AI). Episodes of adrenal crisis (AC) are extremely rare.To address the discordance between the prevalence of biochemical AI and AC, we re-examined the biochemical definition of AI during ICS therapy. We then investigated the utility of early morning salivary cortisol (EMSC) and cortisone (EMSCn) for the identification of patien...

Background: Bardet Biedl syndrome (BBS) is a rare autosomal recessive disorder caused by ciliary dysfunction. It is characterised by rod cone dystrophy, polydactyly, renal dysfunction, cognitive impairment. Endocrine consequences are thought to include hypogonadism, obesity and polyuria. However little is known about the endocrine and metabolic abnormalities in adult patients.Methods: One hundred and fifty-four patients with BBS were identified through t...

Vandetenib has been used as novel treatment of locally invasive medullary carcinoma of thyroid. We report the use of Vandetenib in a paediatric patient with inoperable medullary carcinoma of thyroid gland. Our patient presented to the dental surgeons at age 12 years with tongue and lip swellings. Biopsy demonstrated mucosal neuromas suggestive of MEN2B. He was clinically euthyroid but had a firm goitre. Ultrasound showed a large heterogenous thyroid mass encasing the common ca...

Annexin A1 (AnxA1), an endogenous glucocorticoid regulated protein, is a pivotal homeostatic regulator of the magnitude of the inflammatory response. We have previously demonstrated that plasma AnxA1 protein is significantly inversely correlated with waist to hip ratio (P=0.017). Given that low-level systemic inflammation is seen in metabolic syndrome-associated chronic pathologies, here, we investigate if AnxA1 is also involved in the regulation of adipose tissue infla...

Obesity is a major worldwide health problem with limited treatment options. Recent research has highlighted the importance of gastrointestinal (GI) nutrient sensing in the regulation of food intake and metabolism. Protein as a macronutrient induces the strongest feeling of satiety per calorie. However, different types of protein have varying effects on appetite, suggesting protein induced satiety may be due to the specific amino acids generated by protein digestion. We have id...